Chicago Fire SC 
| 2012-03-17 | MLS | Montreal Impact | (A) | 1 | - 1 | D | |
| 2012-03-25 | MLS | Philadelphia Union | (H) | 1 | - 0 | W | |
| 2012-04-02 | MLS | Colorado Rapids | (A) | 0 | - 2 | L | |
| 2012-04-16 | MLS | Houston Dynamo | (H) | 1 | - 1 | D | |
| 2012-04-21 | MLS | Toronto FC | (A) | 3 | - 2 | W | |
| 2012-04-29 | MLS | Seattle Sounders FC | (H) | 1 | - 2 | L | |
| 2012-05-04 | MLS | CD Chivas USA | (A) | 2 | - 1 | W | |
| 2012-05-10 | MLS | Real Salt Lake | (H) | 0 | - 0 | D | |
| 2012-05-13 | MLS | Sporting Kansas City | (H) | 2 | - 1 | W | |
| 2012-05-21 | MLS | Portland Timbers | (A) | 1 | - 2 | L | |
| 2012-05-24 | MLS | FC Dallas | (H) | 2 | - 1 | W | |
| 2012-05-27 | MLS | Columbus Crew | (A) | 1 | - 2 | L | |
| 2012-06-03 | MLS | New England Revolution | (A) | 0 | - 2 | L | |
| 2012-06-18 | MLS | New York Red Bulls | (H) | 3 | - 1 | W | |
| 2012-06-24 | MLS | Columbus Crew | (H) | 2 | - 1 | W | |
| 2012-06-30 | MLS | Sporting Kansas City | (A) | 1 | - 0 | W | |
| 2012-07-04 | MLS | Houston Dynamo | (A) | 0 | - 0 | D | |
| 2012-07-08 | MLS | Los Angeles Galaxy | (H) | 0 | - 2 | L | |
| 2012-07-15 | MLS | Vancouver Whitecaps FC | (H) | 1 | - 0 | W | |
| 2012-07-18 | MLS | New York Red Bulls | (A) | 0 | - 1 | L | |
| 2012-07-29 | MLS | San Jose Earthquakes | (A) | 1 | - 1 | D | |
| 2012-08-05 | MLS | Toronto FC | (H) | 2 | - 1 | W | |
| 2012-08-13 | MLS | Philadelphia Union | (A) | 3 | - 1 | W | |
| 2012-08-19 | MLS | New England Revolution | (H) | 2 | - 1 | W | |
| 2012-08-23 | MLS | D.C. United | (A) | 2 | - 4 | L | |
| 2012-09-03 | MLS | Houston Dynamo | (H) | 3 | - 1 | W | |
| 2012-09-13 | MLS | Toronto FC | (A) | 2 | - 1 | W | |
| 2012-09-16 | MLS | Montreal Impact | (H) | 3 | - 1 | W | |
| 2012-09-23 | MLS | Columbus Crew | (H) | 2 | - 1 | W | |
| 2012-09-29 | MLS | Sporting Kansas City | (A) | 0 | - 2 | L | |
| 2012-10-04 | MLS | Philadelphia Union | (H) | 1 | - 3 | L | |
| 2012-10-06 | MLS | New York Red Bulls | (A) | 2 | - 0 | W | |
| 2012-10-21 | MLS | New England Revolution | (A) | 0 | - 1 | L | |
| 2012-10-27 | MLS | D.C. United | (H) | 1 | - 1 | D |