Columbus Crew 
| 2011-03-19 | MLS | D.C. United | (A) | 1 | - 3 | L | |
| 2011-03-26 | MLS | New York Red Bulls | (H) | 0 | - 0 | D | |
| 2011-04-01 | MLS | FC Dallas | (H) | 2 | - 0 | W | |
| 2011-04-10 | MLS | CD Chivas USA | (A) | 0 | - 0 | D | |
| 2011-04-16 | MLS | Sporting Kansas City | (H) | 1 | - 0 | W | |
| 2011-04-23 | MLS | Toronto FC | (A) | 1 | - 1 | D | |
| 2011-04-30 | MLS | Vancouver Whitecaps FC | (H) | 2 | - 1 | W | |
| 2011-05-08 | MLS | Seattle Sounders FC | (H) | 1 | - 1 | D | |
| 2011-05-15 | MLS | San Jose Earthquakes | (A) | 0 | - 3 | L | |
| 2011-05-22 | MLS | Portland Timbers | (A) | 0 | - 1 | L | |
| 2011-05-29 | MLS | CD Chivas USA | (H) | 3 | - 3 | D | |
| 2011-06-05 | MLS | New York Red Bulls | (A) | 1 | - 1 | D | |
| 2011-06-08 | MLS | Real Salt Lake | (H) | 2 | - 1 | W | |
| 2011-06-12 | MLS | Chicago Fire SC | (H) | 0 | - 1 | L | |
| 2011-06-18 | MLS | Houston Dynamo | (A) | 2 | - 0 | W | |
| 2011-06-26 | MLS | Colorado Rapids | (H) | 4 | - 1 | W | |
| 2011-07-02 | MLS | FC Dallas | (A) | 0 | - 2 | L | |
| 2011-07-06 | MLS | Vancouver Whitecaps FC | (A) | 1 | - 0 | W | |
| 2011-07-16 | MLS | San Jose Earthquakes | (H) | 0 | - 0 | D | |
| 2011-07-20 | MLS | Los Angeles Galaxy | (A) | 0 | - 1 | L | |
| 2011-07-23 | MLS | Portland Timbers | (H) | 1 | - 0 | W | |
| 2011-07-30 | MLS | Real Salt Lake | (A) | 2 | - 0 | W | |
| 2011-08-05 | MLS | Colorado Rapids | (A) | 0 | - 2 | L | |
| 2011-08-13 | MLS | New England Revolution | (H) | 3 | - 1 | W | |
| 2011-08-20 | MLS | Philadelphia Union | (H) | 2 | - 1 | W | |
| 2011-08-27 | MLS | Seattle Sounders FC | (A) | 2 | - 6 | L | |
| 2011-09-11 | MLS | Toronto FC | (H) | 2 | - 4 | L | |
| 2011-09-15 | MLS | Houston Dynamo | (H) | 2 | - 2 | D | |
| 2011-09-18 | MLS | Philadelphia Union | (A) | 0 | - 1 | L | |
| 2011-09-25 | MLS | Los Angeles Galaxy | (H) | 0 | - 1 | L | |
| 2011-09-29 | MLS | Sporting Kansas City | (A) | 1 | - 2 | L | |
| 2011-10-02 | MLS | D.C. United | (H) | 2 | - 1 | W | |
| 2011-10-16 | MLS | New England Revolution | (A) | 3 | - 0 | W | |
| 2011-10-23 | MLS | Chicago Fire SC | (A) | 2 | - 3 | L |